Metro Man (Brad Pitt – Oceans 13) and Megamind (Will Ferrell – The Other Guys) have been at each other’s throats since they were kids. Orphaned by the destruction of their home planet, Megamind and Metro Man have led two very different lives. Metro Man has had a privileged upbringing whereas Megamind has been brought up by the inmates of a local jail. Megamind has carried this chip on his shoulder for many years and decides he wants to be rid of his enemy once and for all. One day he actually achieves this goal and destroys Metro Man. But now that he has no nemesis, what will Megamind do with his time?