From Cinelinx:
Well this is interesting. Syfy has said repeatedly that they didn't want a simple re-tread of the classic Terry Gilliam film in their 12 Monkeys TV series, and even though their first trailer looks exactly like it, they're at least changing up our perceptions of the characters. It's been announced that Emily Hampshire (a female if that was unclear) has snagged the role originally played by Brad Pitt (not a female).
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Interesting, loved the film so hopeful for this.