With all the massive collection at the box office for Thor: The Dark World (north of $600 million, recent report states), the possibilities of the other Avenger movies makes it even more probable.
If the Black Panther does make it to the big screen, who would play the role? If the studio can afford, I would definitely want to see Will Smith (massive fan). Or the other possibility would be to see Djimon Hounsou. He is a very versatile actor who could definitely pull it off.