Jeremy of We Got This Covered wrote, "Director Tom Six follows-up his shocking 2009 horror film The Human Centipede with a sequel that promises the "fans" more blood, poop and filth. The Human Centipede 2 [Full Sequence] stays true to those intentions, but that isn't necessarily a good thing. In fact, that's a horrible thing. What kind of worked in the first film doesn't work at all in the sequel. There's nothing even remotely funny about this film or Tom Six as a filmmaker. He proved the world wrong when they said he couldn't make anything sicker than the first Human Centipede, but he also proved that he needs to stop making films."