Jeremy of We Got This Covered wrote, "One of the best films of 2011 came in the form of a cancer dramedy directed by young filmmaker Jonathan Levine and starring Seth Rogen, Anna Kendrick and Joseph Gordon-Levitt. 50/50 hits all the right notes as it walks the fine line of being a hilarious comedy and an emotional drama. It’s authentic, honest and it makes for one hell of a film. The film is anchored by its heart-felt performance by JGL, but Rogen, Kendrick and the rest of the supporting cast help make the ensemble team feel just as important. Levine knows how to find the strengths in his actors and shape-shift the film into a cluster of emotions."