Wilson of The Daily Rotation wrote, "If you have seen the first Human Centipede and thought it was the sickest film out there, I believe this movie is for you. Yes, the first film managed to break some awkward taboos and bring up some disgusting concepts, but let’s be real, there are worse movie out there. You know it, I know it, and Tom Six sure as hell knows it. I think what motivates Tom Six is the fact that people think his work is disgusting, so he has to try and top himself to prove it is in fact not the worst. This is where we get The Human Centipede 2: Full Sequence."