It’s been 10 years since the Woodsboro murders first shocked the nation. Sidney Prescott (Neve Campbell – Party of Five) has written her memoirs of the harrowing ordeal which has now translated into a bestselling self-help book. She comes back to Woodsboro as part of her book tour which coincidentally happens to fall on the anniversary of the massacres. Whilst back home, she reacquaints herself with some old friends. Dewey Riley (David Arquette – Scream) is now the town's Sheriff and his wife Gale (Courteney Cox – Friends) has given up the limelight and is now a struggling author. Before long, a series of grisly murders start up again and everyone is a suspect. Ghostface is back and this time the rules have changed, he wants to make Sidney suffer by targeting her extended family, especially her younger cousin Jill (Emma Roberts – Valentine’s Day) and her high school friends.