Coming Soon says:
Comic-Con 2011 may have hit its biggest reveal today with the first footage of The Amazing Spider-Man's central villain, the Lizard in Hall H.
One of Spider-Man's earliest villains in the comics, the character, created by Stan Lee and Steve Ditko, made his first appearance in "The Amazing Spider-Man" #6. A herpetologist, Dr. Curt Connors inadvertently transformed himself into the reptilian beast while trying to re-grow a missing arm.
In the footage, we see Rhys Ifans talking to Peter Parker's (Andrew Garfield) class about his studies to do exactly that. He's working for Oscorp and Gwen Stacy (Emma Stone) appears to be his lab assistant.