Although she has stated that the AVP series killed the franchise, Sigourney Weaver now says she wants to do another film in the Alien series says Moviehole.net from an interview Sigourney did with Moviefone.
Well, I'm sure she can still kick some ass but I don't know that it would work anymore unless they brought a younger looking version of her back as one of the robots to help out on one of the missions.
I think they are doing the Prequels for the near future.
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