Holly Berenson (Katherine Heigl – The Ugly Truth) and Eric Messer (Josh Duhamel – Transformers) went on a blind date one evening many years ago on the insistence of their respective best friends Alison and Peter Novak (Christina Hendricks – Mad Men and Hayes MacArthur – She’s Out Of My League). It was a monumental failure but both Holly and Eric did share one thing in common, their love for their best friends. One fateful night Holly gets a phone call from the Police telling her that Alison and Peter have died in a car accident. Holly and Eric are both tasked with looking after their baby daughter Sophie in the unfortunate event of their untimely deaths. Now Eric and Holly must put aside their obvious differences and somehow live together to raise Sophie - even though neither one of them is ready to start a family, especially not with one another.