Galifianakis I definitely agree with. His co-star role in Due Date, I think, was enough to show he probably can't lead a cast. John C Reilly, I'd like to see Cyrus to get a full opinion on him. I don't think he's necessary better off as second fiddle in a "can't carry a movie way". And he does great playing a co-leading role (Step Brothers). Though I will agree, I don't think he has the star power to draw a big box office on his own.

Alec Baldwin and JK Simmons I don't particularly care for. Baldwin I can't really stand half the time. Simmons is tolerable, just nothing about him every stands out for me. Cillian Murphy I think is a good actor. And I believe he could lead in indies, just doesn't have that star power to be a box office draw.

Stanley Tucci and Ed Harris are great actors, both. Very respectable. Though, yes, they've definitely made a name for themselves as supporting/character actors. I wouldn't mind seeing them in a lead though. Ed Harris is probably the more capable of the two though.

I agree with a majority of this list. Alec Boldwin had one movie I watched where he was the main guy, and personally i felt it was boring as heck. He is funny and what not as a side person, but too much of him gets lame.

One I don't agree with is Cillian Murphy, I think stuff he has lead has been really great and watchable. I see potential in him and I don't think he should be restricted to just side characters.

Cillian Murphy was brilliant in Sunshine, and Ive admired his acting abilities in Inception and Batman. Red Eye...i didnt really like, maybe because he wasnt suited for a villain role to that degree. He did it well in Batman though, coming off as natural, professional, cool calm and collected, but he went psychotic and ballistic in red eye.