Most horror movies, hoping to elicit a simple visceral response, aim squarely for the gut. Blood? Gore? Ewwww!
Splice, an unsettling, intelligent, and way-out-there experiment in bio-terror from Canadian director Vincenzo Natali, targets the chromosomes. Splicing human with creature DNA? Whoa!
Not since David Cronenberg's sexual-parasite tale The Fly (1986) have I physically experienced horror on the molecular level.