Jeremy of The Daily Rotation wrote, "One of the most important filmmakers currently working today, Steven Soderbergh, is planning on stepping away from the big screen in Hollywood to pursue new artistic adventures. Side Effects has been named his last film to hit theaters and while that may change down the line I must say that he’s picked a perfect film to close on. This pharmaceutical thriller attacks the viewer like a drug to the brain, with its ripe message about America’s obsession with prescription medications right on the front line, while also easing back and uncovering a dirty secret that has its fair share of twists and turns. Soderbergh directs Side Effects much like his pandemic movie Contagion, but with a much sharper eye and a stronger and more focused sense of storytelling. I know it’s early in the year, but Side Effects is as of this moment the best film I’ve seen this year."