Jeremy of The Daily Rotation wrote, "Lorene Scafaria makes her directorial debut with Seeking a Friend for the End of the World. Up until this point she’s only written an episode of Childrens Hospital, plus Nick and Norah’s Infinite Playlist. She branches off from the softer comedy to tackle something much more serious and depressing. Seeking a Friend approaches the end of the world with a very real sense of danger, hopelessness and eventually fulfillment. Steve Carell and Keira Knightley light up the screen with dramatic, yet charming performances; while occasional cameos help bring everything together. Seeking a Friend is an exceptional end of the world drama that’s sincere and open, with only a few sophomore hiccups."